Multiple myeloma, a rare but relentless form of cancer, often remains undiagnosed until it reaches advanced stages. While many associate it with bone pain and fatigue, there are several lesser-known signs that can act as important indicators for early detection. This article delves into these often-overlooked symptoms, shedding light on the subtler nuances of multiple myeloma. Recognizing the lesser-known signs and symptoms is essential for early detection and timely intervention. Subtle bone changes Besides the more conspicuous bone pain, multiple myeloma can manifest as subtle bone changes. These may include thinning bones, tiny fractures, or a higher susceptibility to fractures, especially in the spine or hips. These changes can be early hints of the disease and should not be ignored, especially in older individuals. Renal issues Kidney problems can be an insidious indicator of multiple myeloma. When this cancer progresses, it can accumulate abnormal proteins in the kidneys, causing damage. Signs of renal involvement may include increased thirst, frequent urination, and swelling, particularly in the legs and ankles. Monitoring kidney health is crucial for patients at risk. Neuropathy Nerve damage, or neuropathy, can be an unexpected sign of multiple myeloma. Patients might experience tingling sensations, weakness, or even loss of sensation in their extremities.